The Fate of Type I Angiotensin Ii Receptor after Biased Activation
نویسنده
چکیده
Supervisors: Dr. László Hunyady, DSc, professor Dr. András Balla, PhD, associate professor Official reviewers: Dr. Károly Liliom, PhD, senior research fellow Dr. Attila Reményi, PhD , senior research fellow Head of the Final Examination Committee: Dr. Zsuzsanna Fürst, DSc, professor emerita Members of the Final Examination Committee: Dr. Szabolcs Sipeki, PhD, senior lecturer Dr. Beáta Sperlágh, DSc , scientific advisor
منابع مشابه
Investigation of the fate of type I angiotensin receptor after biased activation.
Biased agonism on the type I angiotensin receptor (AT1-R) can achieve different outcomes via activation of G protein-dependent and -independent cellular responses. In this study, we investigated whether the biased activation of AT1-R can lead to different regulation and intracellular processing of the receptor. We analyzed β-arrestin binding, endocytosis, and subsequent trafficking steps, such ...
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